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Schneider-Helmert and colleagues administered DSIP intravenously to patients with chronic insomnia and to normal volunteers, using doses in the range of approximately 20 to 40 mcg per kilogram body weight

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Although most studies have claimed sufficient biocompatibility in their reports, the integrity and function of the BBB after treatment should also be verified, which is pivotal to maintaining the homeostasis of the brain microenvironment